MicroRNA Function Can Be Reversed by Altering Target Gene Expression Levels

Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown be pro-apoptotic some studies, but anti-apoptotic others. To investigate this phenomenon, we combine computational modeling with experimental approaches examine how the function of apoptosis varies respect expression levels its and targets. In so doing, elucidate a general trend that is more targets are overexpressed, while it overexpressed. We show possible completely reverse miR-125b’s by modifying target genes. Furthermore, may also altered presence anticancer drugs. These results suggest microRNA can vary substantially dependent on gene levels.